The Collaborative Research Center (Sonderforschungsbereich, SFB) 1078 "Protonation Dynamics in Protein Function" is a research platform, which was initiated and is coordinated by the Freie Universität Berlin (FU). Participating institutions are the Technische Universität Berlin (TU), the Humboldt-Universität zu Berlin (HU), the Charité - Universitätsmedizin Berlin, the Leibniz-Institut für Molekulare Pharmakologie (FMP), the Justus-Liebig-Universität Gießen (JLU) and the Hebrew University of Jerusalem in Israel (HUJI). The SFB is funded by the German Research Foundation (DFG) for a third period of 4 years (Jan. 2021 - Dec. 2024).

The central research goal of the SFB 1078 is to identify and understand a new key principal in protein science, namely the control and coordination of complex protein function by protonation dynamics. To this end, the SFB comprises 19 research projects led by 22 principal investigators (PIs) with a diverse expertise in physics, chemistry, and biology. The SFB also hosts an Intergrated Graduate School for the advanced training of PhD students.

Spokesperson of the SFB 1078 is Prof. Dr. Joachim Heberle (FU) with two deputy spokespersons Prof. Dr. Holger Dau (FU) and Prof. Dr. Maria Andrea Mroginski (TU) .